This is a video meant to speak to doctors and it includes captions that help the layperson understand.

We’ll be reviewing the evidence-based medical research on cannabinoids as a potential therapy of choice in modern neuro-oncology, their effects on tumor cells, the synergistic role they play in chemotherapy treatments, as well as their neuroprotective properties. We will also discuss one of the most important antitumoral strategies explored in recent years, addressing how cannabis can inhibit the growth of new blood vessels to tumors (anti-angiogenesis). More specifically the physiologic mechanism describing how cannabinoids inhibits vascular endothelial growth factor (VEGF) and the positive downstream effects this has on rapidly growing cancer. This video is a high yield summary of the therapeutic and supportive effects of Cannabinoids for patients with cancer.

Our review today will reveal the evidence on these subjects:

- The 3 necessary components for cancer to exist
- The antitumor effects of cannabinoids
- Tumor cell growth and proliferation control
- Cannabinoid-induced cell death (pro-apoptosis)
- Anti-angiogenic effects of cannabis
- Inhibition of the production and signaling of the vascular endothelial growth factor (VEGF) pathway

CITATIONS FOR RESEARCH:
Rodriguez-Almaraz JE, Butowski N. Therapeutic and Supportive Effects of Cannabinoids in Patients with Brain Tumors (CBD Oil and Cannabis). Curr Treat Options Oncol. 2023;24(1):30-44. doi:10.1007/s11864-022-01047-y
@3/

Blázquez C, González-Feria L, Alvarez L, Haro A, Casanova ML, Guzmán M. Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res. 2004;64(16):5617-5623. doi:10.1158/0008-5472.CAN-03-3927
@9/

Twelves, C., Sabel, M., Checketts, D. et al. A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid oromucosal spray with temozolomide in patients with recurrent glioblastoma. Br J Cancer 124, 1379–1387 (2021). @/s41416-021-01259-3

** The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional.

** Disclosures: References to off label use of pharmaceuticals - Cannabis is not FDA-approved.

**This video is under Fair Use: Copyright Disclaimer Under Section 107 of the Copyright Act in 1976; Allowance is made for "Fair Use” for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. All rights and credit go directly to its rightful owners. No copyright infringement intended.

About Dr. Thomas Henke, D.O.

Dr. Henke is an osteopathic physician with over a decade of experience in the medical field. He is an expert in the field to Cannabis and Cannabinoid therapy management. He provides medical care as a physician, and consultations as an expert Cannabis consultant and medical Cannabis coach. As medical director of Source Medical Solutions, he provides medical care to patients via telemedicine at Henkemed.com. He owns and operates sourcemedicalclinic.com (a subsidiary of SMS) for patients who seek their medical Cannabis card and/or coaching. 

Click the Learn More Button to Subscribe to Dr. Henke's YouTube Channel

Effective Cannabis Newsletter is a platform to educate on the vital role of the Endocannabinoid System (ECS) in one's health. The information is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. All content, including text, graphics, images, and information, contained in or available through this newsletter is for general information purposes only. It is not medical advice; it is health awareness.